Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood


Abstract

Introduction: Keratoacanthoma (KA) is a common neoplasm and one of variety squamous cell carcinoma (SCC) characterized by rapid growth with potential for tissue damage.
Case Presentation: A 64-year-old man presented with hyperkeratotic papules that initially appeared on the dorsum of his hand and slowly progressed to form a large annular plaque along with multiple small keratotic plaques and papules. He was depressed and worried about the appearance and lesions. He had a history of multiple surgery on the lesions that had recurrence and finally the surgeon decided to do extensive excision with flap that had recurrence on the donor and recipient site, too. Treatment with Acitretin was started. Evolution of new lesions had decreased and stable lesions had begun to regress.
Conclusions: Although the gold standard for the treatment of keratoacanthoma is surgical excision, oral retinoid can be a good choice for multiple recurrent keratoacanthoma.

Keywords

Keratoacanthoma; Neoplasm; Acitretin

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood


Authors

Mohammad Ebrahimzadeh Ardakani

Affiliation: Department of Dermatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Fariba Binesh

Affiliation: Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Narges Ghanei

E-mail: Nargesgh73@yahoo.com
Affiliation: Department of Dermatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mojtaba Babaei Zarch

Affiliation: Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood


References

1. Rambhia SH, Rambhia KD, Gulati A. A rare case of multiple keratoacanthomas treated with oral acitretin and intralesional methotrexate. Indian Dermatol Online J. 2016;7(4):321-3. DOI: 10.4103/2229-5178.185480 PMID: 27559516
2. Kwiek B, Schwartz RA. Keratoacanthoma (KA): An update and review. J Am Acad Dermatol. 2016;74(6):1220-33. DOI: 10.1016/j.jaad.2015.11.033 PMID: 26853179
3. Schwartz RA. Keratoacanthoma: a clinico-pathologic enigma. Dermatol Surg. 2004;30(2 Pt 2):326-33; discussion 33. PMID: 14871228
4. Schwartz RA. Keratoacanthoma. J Am Acad Dermatol. 1994;30(1):1-19; quiz 20-2. PMID: 8277007
5. Ka_Zmierowski M, Bowszyc-Dmochowska M. Multiple keratoacanthomas treated with cryosurgery and retinoids. Postepy Dermatol. 1997;14:397-402.
6. Street ML, White JW, Jr., Gibson LE. Multiple keratoacanthomas treated with oral retinoids. J Am Acad Dermatol. 1990;23(5 Pt 1):862-6. PMID: 2254471
7. Karaa A, Khachemoune A. Keratoacanthoma: a tumor in search of a classification. Int J Dermatol. 2007;46(7):671-8. DOI: 10.1111/j.1365-4632.2007.03260.x PMID: 17614793
8. Lain EL, Markus RF. Early and explosive development of nodular basal cell carcinoma and multiple keratoacanthomas in psoriasis patients treated with cyclosporine. J Drugs Dermatol. 2004;3(6):680-2. PMID: 15624753
9. Allen JV, Callen JP. Keratoacanthomas arising in hypertrophic lichen planus. A case report. Arch Dermatol. 1981;117(8):519-21. PMID: 7259250
10. Paul MA, Stonecipher MR, Abernethy J, Leshin B, White WL, Jorizzo JL. Multiple keratoacanthomas in hypertrophic lichen planus: treatment with systemic retinoids (etretinate). J Eur Acad Dermatol Venereol. 1994;3(3):320-5. DOI: 10.1111/j.1468-3083.1994.tb00369.x
11. Goldberg LH, Silapunt S, Beyrau KK, Peterson SR, Friedman PM, Alam M. Keratoacanthoma as a postoperative complication of skin cancer excision. J Am Acad Dermatol. 2004;50(5):753-8. DOI: 10.1016/j.jaad.2003.11.065 PMID: 15097960
12. Hadley JC, Tristani-Firouzi P, Florell SF, Bowen GM, Hadley ML. Case series of multiple recurrent reactive keratoacanthomas developing at surgical margins. Dermatol Surg. 2009;35(12):2019-24. DOI: 10.1111/j.1524-4725.2009.01327.x PMID: 19758354
13. Chesnut GT, Maggio KL, Turiansky GW. Letter: Re: Case series of multiple recurrent reactive keratoacanthomas developing at surgical margins. Dermatol Surg. 2011;37(6):884-5. DOI: 10.1111/j.1524-4725.2011.01962.x PMID: 21492306
14. de la Torre C, Losada A, Cruces MJ. Keratoacanthoma centrifugum marginatum: treatment with intralesional bleomycin. J Am Acad Dermatol. 1997;37(6):1010-1. PMID: 9418780
15. Yuge S, Godoy DA, Melo MC, Sousa DS, Soares CT. Keratoacanthoma centrifugum marginatum: response to topical 5-fluorouracil. J Am Acad Dermatol. 2006;54(5 Suppl):S218-9. DOI: 10.1016/j.jaad.2005.07.023 PMID: 16631944
16. Bruscino N, Corradini D, Campolmi P, Massi D, Palleschi GM. Superficial radiotherapy for multiple keratoacanthomas. Dermatol Ther. 2014;27(3):163-7. PMID: 25032245
17. Aydin F, Senturk N, Sabanciler E, Canturk MT, Turanli AY. A case of Ferguson-Smith type multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum: response to oral acitretin. Clin Exp Dermatol. 2007;32(6):683-6. DOI: 10.1111/j.1365-2230.2007.02498.x PMID: 17714527

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood


Citation tools

Vancouver

Ebrahimzadeh Ardakani M, Binesh F, Ghanei N, Babaei Zarch M. Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood. Focus on Sciences. 2106; 3(2):1-3


APA

Ebrahimzadeh Ardakani, M., Binesh, F., Ghanei, N., & Babaei Zarch, M. (2106). Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood. Focus on Sciences, 3(2), 1-3.


Chicago

Mohammad Ebrahimzadeh Ardakani, Fariba Binesh, Narges Ghanei, and Mojtaba Babaei Zarch "Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood". Focus on Sciences 3, no. 2 (2106).

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood


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